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pentobarbital will decrease the extent or influence of voriconazole by impacting hepatic enzyme CYP2C9/10 metabolism. Small/Significance Mysterious.Barbiturates can induce hepatic microsomal enzymes causing elevated metabolism and decreased anticoagulant response of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); cl